The roles of receptor and ligand endocytosis in regulating Notch signaling

Development. 2005 Apr;132(8):1751-62. doi: 10.1242/dev.01789.

Abstract

Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Drosophila Proteins
  • Endocytosis / physiology*
  • Gene Expression Regulation, Developmental*
  • Juvenile Hormones / metabolism
  • Ligands
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Models, Biological*
  • Proteins / metabolism
  • Receptors, Notch
  • Signal Transduction / physiology*
  • Ubiquitin / metabolism
  • Wiskott-Aldrich Syndrome Protein

Substances

  • Drosophila Proteins
  • Juvenile Hormones
  • Ligands
  • Membrane Proteins
  • Proteins
  • Receptors, Notch
  • Ubiquitin
  • Wiskott-Aldrich Syndrome Protein
  • numb protein, Drosophila