Abstract
We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosphorylation in a recombinant vaccinia virus system.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / analogs & derivatives*
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Acyclovir / therapeutic use
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Adolescent
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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Chemoprevention
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Codon
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Cytomegalovirus / drug effects*
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Cytomegalovirus / genetics
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Cytomegalovirus Infections / drug therapy
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Cytomegalovirus Infections / virology
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Drug Resistance, Viral / genetics*
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Ganciclovir / metabolism
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Ganciclovir / pharmacology*
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Ganciclovir / therapeutic use
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Humans
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Kidney Transplantation / adverse effects*
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Molecular Sequence Data
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Phosphorylation
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Phosphotransferases (Alcohol Group Acceptor) / genetics*
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Sequence Deletion*
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Valacyclovir
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Valine / analogs & derivatives*
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Valine / therapeutic use
Substances
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Antiviral Agents
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Codon
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Phosphotransferases (Alcohol Group Acceptor)
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ganciclovir kinase
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Valine
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Valacyclovir
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Ganciclovir
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Acyclovir