Abstract
Flocculosin, a glycolipid isolated from the yeast-like fungus Pseudozyma flocculosa, was investigated for in vitro antifungal activity. The compound displayed antifungal properties against several pathogenic yeasts. Synergistic activity was observed between flocculosin and amphotericin B, and no significant cytotoxicity was demonstrated when tested against human cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / pharmacology*
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Antifungal Agents / metabolism
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Antifungal Agents / pharmacology*
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Cellobiose / analogs & derivatives*
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Cellobiose / biosynthesis
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Cellobiose / pharmacology*
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Drug Synergism
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Fungi / drug effects*
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Glycolipids / biosynthesis
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Glycolipids / pharmacology*
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Humans
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Microbial Sensitivity Tests
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Mycoses / microbiology
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Ustilaginales / metabolism*
Substances
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2-(2',4'-diacetoxy-5'-carboxypentanoyl)octadecylcellobioside
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Antifungal Agents
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Glycolipids
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Cellobiose
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Amphotericin B