Pharmacology of palliative medicine

Semin Oncol Nurs. 2005 Feb;21(1):29-35. doi: 10.1053/j.soncn.2004.10.005.

Abstract

Objective: To describe the concepts of both pharmacokinetics and pharmacodynamics and how it applies to palliative medicine.

Data sources: Research and review articles and textbooks.

Conclusion: Most patients who have an illness that requires palliation are elderly, have co-morbid conditions, and are on many medications. Both age and disease can alter the way drugs are handled by the body (pharmacokinetics) and how they affect the body (pharmacodynamics).

Implications for nursing practice: The oncology nurse, armed with the correct knowledge about medications, can have an important inmpact on improving the patient's care, safety, and quality of life.

Publication types

  • Review

MeSH terms

  • Biological Availability
  • Comorbidity
  • Cytochrome P-450 Enzyme System / drug effects
  • Cytochrome P-450 Enzyme System / physiology
  • Drug Interactions
  • Drug Monitoring / methods
  • Drug Monitoring / nursing
  • Drug Therapy, Combination*
  • Humans
  • Intestinal Absorption
  • Metabolic Clearance Rate
  • Neoplasms / complications
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism*
  • Neoplasms / nursing
  • Oncology Nursing / methods
  • Palliative Care / methods*
  • Patient Selection
  • Pharmacokinetics
  • Pharmacology
  • Safety Management / methods
  • Tissue Distribution

Substances

  • Cytochrome P-450 Enzyme System