Abstract
In vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2"-acetate (1), phloridzin (2) and trilobatin (3), were investigated. The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 microM, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 microM, respectively, and showed only weak DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antioxidants / isolation & purification*
-
Antioxidants / pharmacology
-
Biphenyl Compounds
-
Chalcone / analogs & derivatives*
-
Chalcone / chemistry*
-
Chalcone / isolation & purification
-
Chalcone / pharmacology
-
Chalcones
-
Fagaceae / chemistry*
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / isolation & purification
-
Free Radical Scavengers / pharmacology*
-
Glucosides
-
Glutathione Peroxidase / metabolism
-
Hydrazines
-
Lipid Peroxidation / drug effects
-
Liver / drug effects
-
Liver / metabolism
-
Picrates
-
Plant Leaves / chemistry*
-
Rats
-
Superoxide Dismutase / metabolism
Substances
-
Antioxidants
-
Biphenyl Compounds
-
Chalcones
-
Free Radical Scavengers
-
Glucosides
-
Hydrazines
-
Picrates
-
Chalcone
-
1,1-diphenyl-2-picrylhydrazyl
-
Glutathione Peroxidase
-
Superoxide Dismutase
-
dihydrochalcone