Hepatic failure in a child with anti-epileptic hypersensitivity syndrome

Albert M Li; Edmund As Nelson; Ellis K L Hon; Frankie W T Cheng; Dorothy F Y Chan; Ngai Chuen Sin; Kwok Chiu Ma; Kam Lau Cheung; Tai Fai Fok

doi:10.1111/j.1440-1754.2005.00591.x

Hepatic failure in a child with anti-epileptic hypersensitivity syndrome

J Paediatr Child Health. 2005 Apr;41(4):218-20. doi: 10.1111/j.1440-1754.2005.00591.x.

Authors

Albert M Li¹, Edmund As Nelson, Ellis K L Hon, Frankie W T Cheng, Dorothy F Y Chan, Ngai Chuen Sin, Kwok Chiu Ma, Kam Lau Cheung, Tai Fai Fok

Affiliation

¹ Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong. [email protected]

Abstract

An 11-year-old boy developed severe hypersensitivity reaction to phenobarbitone resulted in fulminant hepatic failure. During the course of illness, he developed clinical features compatible with severe acute respiratory syndrome (SARS) that may have complicated the recovery of his underlying hypersensitivity reaction, which was subsequently controlled with intravenous immune globulin and corticosteroids.

Publication types

Case Reports

MeSH terms

Anticonvulsants / adverse effects*
Child
Drug Hypersensitivity / complications*
Drug Hypersensitivity / physiopathology
Humans
Immunoglobulins, Intravenous / therapeutic use*
Liver Failure, Acute / complications*
Liver Failure, Acute / physiopathology
Male
Phenobarbital / adverse effects*
Seizures / drug therapy
Severe Acute Respiratory Syndrome / drug therapy*
Severe Acute Respiratory Syndrome / physiopathology

Substances

Anticonvulsants
Immunoglobulins, Intravenous
Phenobarbital