Abstract
Explicit biochemical models have been elaborated for the circadian oscillators of cyanobacterial, fungal, insect, and mammalian species. In contrast, much remains to be learned about how such circadian oscillators regulate rhythmic physiological processes. This article summarizes contemporary genetic and biochemical strategies that are useful for identifying gene products that have a role in circadian control.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Biological Clocks / drug effects*
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Biological Clocks / genetics
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Brain Chemistry
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Circadian Rhythm / drug effects*
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Circadian Rhythm / genetics
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Cyclic AMP / metabolism
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Cyclic AMP Response Element-Binding Protein / physiology
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DNA-Binding Proteins / genetics
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Drosophila Proteins / genetics
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Drosophila Proteins / physiology
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Drosophila melanogaster / genetics
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Fragile X Mental Retardation Protein / genetics
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Fragile X Mental Retardation Protein / physiology
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Genes, Insect / physiology*
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Larva / physiology
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MAP Kinase Signaling System / physiology
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Microarray Analysis / methods
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Motor Activity / genetics
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RNA, Messenger / metabolism
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RNA-Binding Proteins / physiology
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Suprachiasmatic Nucleus / physiology
Substances
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Cyclic AMP Response Element-Binding Protein
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DNA-Binding Proteins
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Drosophila Proteins
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FMR1 protein, Drosophila
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Lark protein, Drosophila
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RNA, Messenger
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RNA-Binding Proteins
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e protein, Drosophila
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Fragile X Mental Retardation Protein
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Cyclic AMP