Trophoblast apoptosis is increased in women with evidence of TH1 immunity

Jiae Lee; Bum-Chae Choi; Chunghee Cho; Joseph A Hill; Kwang-Hyun Baek; Jeong-Wook Kim

doi:10.1016/j.fertnstert.2004.07.979

Trophoblast apoptosis is increased in women with evidence of TH1 immunity

Fertil Steril. 2005 Apr;83(4):1047-9. doi: 10.1016/j.fertnstert.2004.07.979.

Authors

Jiae Lee¹, Bum-Chae Choi, Chunghee Cho, Joseph A Hill, Kwang-Hyun Baek, Jeong-Wook Kim

Affiliation

¹ Laboratory of Reproductive Medicine, Center for Recurrent Miscarriage and Infertility, Creation and Love Women's Hospital, Kwangju Institute of Science and Technology (K-JIST), 13-21 Gwangchun-Dong, Seo-Gu, Gwangju 502-210, Korea.

PMID: 15820826
DOI: 10.1016/j.fertnstert.2004.07.979

Abstract

Interferon-gamma secretion from peripheral blood mononuclear cells (PBMCs) of women with unexplained recurrent spontaneous abortions was increased by trophoblast stimulation. Apoptosis was significantly increased in trophoblast cells cultured with the supernatant of PBMCs from women with evidence of T(H)1 immunity to trophoblast stimulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Habitual / immunology*
Apoptosis / immunology*
Cells, Cultured
Female
Humans
Interferon-gamma / metabolism
Pregnancy
Th1 Cells / immunology*
Th1 Cells / metabolism
Trophoblasts / immunology*
Trophoblasts / pathology*

Substances

Interferon-gamma