An old target revisited: two new privileged skeletons and an unexpected binding mode for HIV-protease inhibitors

Angew Chem Int Ed Engl. 2005 May 13;44(20):3140-4. doi: 10.1002/anie.200462643.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Drug Design*
  • Drug Evaluation, Preclinical
  • HIV Protease Inhibitors / chemical synthesis*
  • HIV Protease Inhibitors / chemistry*
  • Humans
  • Hydrogen Bonding
  • Models, Molecular
  • Molecular Structure
  • Structure-Activity Relationship
  • Sulfones / chemical synthesis*
  • Sulfones / chemistry*

Substances

  • HIV Protease Inhibitors
  • Sulfones