Anaerobic sepsis due to multidrug-resistant Bacteroides fragilis: microbiological cure and clinical response with linezolid therapy

Clin Infect Dis. 2005 Apr 1;40(7):e67-8. doi: 10.1086/428623. Epub 2005 Mar 2.

Abstract

We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, beta-lactams, beta lactam/beta-lactamase inhibitors, carbapenems, macrolides, and tetracyclines. Microbiological cure and clinical improvement was achieved with linezolid therapy, an agent that may be useful for the treatment of multidrug-resistant anaerobic infections.

MeSH terms

  • Acetamides / therapeutic use*
  • Anti-Bacterial Agents / therapeutic use
  • Bacteroides Infections / microbiology*
  • Bacteroides fragilis / physiology*
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Humans
  • Linezolid
  • Microbial Sensitivity Tests
  • Middle Aged
  • Oxazolidinones / therapeutic use*
  • Sepsis / drug therapy*
  • Sepsis / microbiology*

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid