Abstract
A bispecific antibody against carcinoembryonic antigen (CEA) and ricin A chain has been shown to localise in a CEA-producing human tumour xenograft. When labelled recombinant ricin A chain was subsequently injected there was uptake into tumours, indicating that this bispecific antibody can capture or carry toxin into tumour deposits.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / therapeutic use*
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Carcinoembryonic Antigen / analysis*
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Carcinoembryonic Antigen / immunology
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Carcinoma / therapy*
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Humans
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Immunotoxins / administration & dosage*
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Recombinant Proteins / immunology
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Recombinant Proteins / therapeutic use
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Ricin / immunology
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Ricin / therapeutic use*
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Stomach Neoplasms / therapy*
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Transplantation, Heterologous
Substances
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Antibodies, Monoclonal
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Carcinoembryonic Antigen
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Immunotoxins
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Recombinant Proteins
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Ricin