An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey

Mol Pharm. 2004 Jan 12;1(1):97-100. doi: 10.1021/mp034017a.
No abstract available

MeSH terms

  • Administration, Oral
  • Animals
  • Azepines / pharmacokinetics*
  • Azepines / pharmacology
  • Biological Availability
  • Cathepsin K
  • Cathepsins / metabolism*
  • Cysteine Proteinase Inhibitors / pharmacokinetics*
  • Cysteine Proteinase Inhibitors / pharmacology
  • Humans
  • Rats

Substances

  • Azepines
  • Cysteine Proteinase Inhibitors
  • Cathepsins
  • CTSK protein, human
  • Cathepsin K
  • Ctsk protein, rat