Abstract
A known monoalkyl glycerol ether, (+/-)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkadienes / chemistry
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Alkadienes / isolation & purification*
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Animals
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Anthozoa / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Ceramides / chemistry
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Ceramides / isolation & purification*
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Drug Screening Assays, Antitumor
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Glyceryl Ethers / chemistry
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Glyceryl Ethers / isolation & purification*
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Glyceryl Ethers / pharmacology
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Humans
Substances
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(2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol
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1-nonadecyloxy-2,3-propanediol
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Alkadienes
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Antineoplastic Agents
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Ceramides
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Glyceryl Ethers