Abstract
A 33-mer peptide of the alpha-gliadin component of gluten was recently identified as primary initiator of the inflammatory response to gluten in coeliac disease (CD) patients. This proline-glutamine-rich peptide (PG-peptide) is highly homologous to internal sequence of pertactin, an immunogenic protein of Bordetella pertussis. Using enzyme immunoassays, we measured serum antibodies to pertactin and to PG-peptide in 167 Finnish subjects including pertussis vaccine recipients and pertussis patients, CD and non-CD patients and healthy individuals. We found no cross-reactivity between human antibodies to the two different components, suggesting that neither pertussis immunization nor disease contributes to the pathogenesis of CD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antibodies, Bacterial / analysis
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Antibodies, Bacterial / biosynthesis*
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Antibody Specificity
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Bacterial Outer Membrane Proteins / chemistry
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Bacterial Outer Membrane Proteins / immunology*
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Bordetella pertussis / chemistry
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Bordetella pertussis / immunology*
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Child
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Child, Preschool
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Cross Reactions
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Enzyme-Linked Immunosorbent Assay
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Female
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Finland
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Gliadin / immunology*
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Glutens / immunology*
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Humans
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Immunoglobulin A / analysis
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Immunoglobulin A / immunology
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Immunoglobulin G / analysis
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Immunoglobulin G / immunology
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Male
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Middle Aged
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Virulence Factors, Bordetella / chemistry
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Virulence Factors, Bordetella / immunology*
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Whooping Cough / immunology
Substances
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Antibodies, Bacterial
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Bacterial Outer Membrane Proteins
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Immunoglobulin A
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Immunoglobulin G
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Virulence Factors, Bordetella
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pertactin
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Glutens
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Gliadin