Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

Br J Clin Pharmacol. 2005 May;59(5):602-4. doi: 10.1111/j.1365-2125.2005.02354.x.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Area Under Curve
  • Heterozygote
  • Histamine H1 Antagonists / pharmacokinetics*
  • Humans
  • Liver-Specific Organic Anion Transporter 1
  • Organic Anion Transport Protein 1 / genetics*
  • Organic Anion Transporters / genetics
  • Organic Anion Transporters, Sodium-Independent / genetics*
  • Polymorphism, Genetic*
  • Terfenadine / analogs & derivatives*
  • Terfenadine / pharmacokinetics

Substances

  • Histamine H1 Antagonists
  • Liver-Specific Organic Anion Transporter 1
  • Organic Anion Transport Protein 1
  • Organic Anion Transporters
  • Organic Anion Transporters, Sodium-Independent
  • SLCO1B1 protein, human
  • Terfenadine
  • fexofenadine