Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with Grignard reagents

J Org Chem. 2005 Apr 29;70(9):3734-6. doi: 10.1021/jo050015l.

Abstract

[reaction: see text] Simple Grignard reagents were applied in copper-catalyzed asymmetric ring-opening reactions of oxabenzonorbornadiene derivatives using spiro phosphoramidite ligands. Excellent anti-stereoselectivities and good enantioselectivities were achieved.