Abstract
The role of tumor necrosis factor alpha (TNF-alpha) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-alpha p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-alpha plays a role in the acceleration of atherosclerosis by C. pneumoniae.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arteriosclerosis / microbiology*
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Arteriosclerosis / physiopathology*
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Chlamydophila Infections / microbiology
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Chlamydophila Infections / physiopathology
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Chlamydophila pneumoniae / metabolism
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Chlamydophila pneumoniae / pathogenicity*
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Hyperlipidemias / microbiology*
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Hyperlipidemias / physiopathology*
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Receptors, Tumor Necrosis Factor / genetics
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Receptors, Tumor Necrosis Factor, Type I
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Type I
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha
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recombinant human tumor necrosis factor-binding protein-1