Abstract
Compared to C57BL/6 wild-type mice, interleukin-15(-/-) (IL-15(-/-)) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell and NK cell functions, and lower titers of malaria-specific antibodies. Thus, IL-15 supports early control and timely resolution of blood-stage malaria through promotion of Th1-dependent innate and adaptive immune responses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Protozoan / blood
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Cytokines / blood
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Dendritic Cells / immunology
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Immunity, Innate
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Interleukin-15 / genetics
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Interleukin-15 / immunology*
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Killer Cells, Natural / immunology
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Malaria / immunology*
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Malaria / mortality
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Malaria / parasitology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Parasitemia / immunology*
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Parasitemia / mortality
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Parasitemia / parasitology
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Plasmodium chabaudi / immunology
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Plasmodium chabaudi / pathogenicity*
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Th1 Cells / immunology
Substances
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Antibodies, Protozoan
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Cytokines
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Interleukin-15