Abstract
The importance in vivo of P2X7 receptors in control of virulent Mycobacterium tuberculosis was examined in a low-dose aerosol infection mouse model. P2X7(-/-) mice controlled infection in lungs as well as wild-type mice, suggesting that the P2X7 receptor is not required for control of pulmonary M. tuberculosis infection.
MeSH terms
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Animals
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Antigen Presentation
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology
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Lung / immunology
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Lung / microbiology
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Lymph Nodes / immunology
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Lymph Nodes / microbiology
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Macrophages / immunology
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Macrophages / microbiology
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Mice
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Mice, Inbred C57BL
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Mycobacterium tuberculosis / pathogenicity*
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Receptors, Purinergic P2 / metabolism*
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Receptors, Purinergic P2X7
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Tuberculosis, Pulmonary / immunology*
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Tuberculosis, Pulmonary / microbiology
Substances
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P2rx7 protein, mouse
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Receptors, Purinergic P2
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Receptors, Purinergic P2X7