Fluorinated alpha-aminophosphonates--a new type of irreversible inhibitors of serine hydrolases

Dokl Biochem Biophys. 2005 Jan-Feb:400:92-5. doi: 10.1007/s10628-005-0041-7.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biochemistry / methods
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology
  • Enzyme Inhibitors / pharmacology*
  • Fluorine / chemistry
  • Fluorine / pharmacology*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Models, Theoretical
  • Organophosphonates / pharmacology*
  • Serine Endopeptidases / chemistry
  • Serine Endopeptidases / metabolism*
  • Time Factors

Substances

  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Organophosphonates
  • Fluorine
  • Serine Endopeptidases