[Surgical therapy of primary hyperparathyroidism and it's complications. Experience with 453 patients]

Zentralbl Chir. 2005 Apr;130(2):109-13. doi: 10.1055/s-2005-836365.
[Article in German]

Abstract

453 patients underwent surgery for primary hyperparathyreoidism between 1994 and 2003. In all patients, biochemical parameters were monitored and X-ray with USG of the neck was done. Struma nodosa was concommitantly present in 48 % of treated patients with primary hyperparathyroidism. In such cases, MRI offers better resolution of soft tissues. 98.6 % of treated patients had postoperative decrease of blood calcium to normal level. 5.4 % of cases were reoperations for primary hyperparathyroidism. In 12 % of cases, pathologically changed parathyroid glands in dystopic localization were found. In these dystopic localizations, pathologic parathyroid glands were found: in 3 % intrathyroid, in 7 % mediastinal and in 2 % of all 453 cases in other localization. In 4 % of patients, sternotomy was necessary. Persistent hypocalcemia was not registered in any patient. Transient hypocalcemia with necessity of infusion therapy was observed in 3.5 % of patients. Postoperative hypercalcemia persisted in 1.2 % of patients. Recurrent hypercalcemia was present in 0.2 % of cases. In three cases (0.7 %), unilateral injury of recurrent laryngeal nerve was observed.

Publication types

  • Comparative Study

MeSH terms

  • Adenoma / surgery*
  • Adolescent
  • Adult
  • Aged
  • Child
  • Diagnosis, Differential
  • Female
  • Goiter, Nodular / diagnosis
  • Humans
  • Hypercalcemia / etiology
  • Hyperparathyroidism / blood
  • Hyperparathyroidism / diagnosis
  • Hyperparathyroidism / surgery*
  • Hyperplasia
  • Intraoperative Complications
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neck / diagnostic imaging
  • Parathyroid Glands / abnormalities
  • Parathyroid Glands / pathology
  • Parathyroid Hormone / blood
  • Parathyroid Neoplasms / surgery*
  • Postoperative Complications
  • Radiography
  • Recurrence
  • Recurrent Laryngeal Nerve Injuries
  • Reoperation
  • Risk Factors
  • Ultrasonography

Substances

  • Parathyroid Hormone