Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones

Jeff Powis; Allison McGeer; Carla Duncan; Ryan Goren; Joyce C S de Azavedo; Darrin J Bast; Sylvia Pong-Porter; Tony Mazzulli; Karen Green; Barbara Willey; Donald E Low

doi:10.1128/AAC.49.5.2130-2132.2005

Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones

Antimicrob Agents Chemother. 2005 May;49(5):2130-2. doi: 10.1128/AAC.49.5.2130-2132.2005.

Authors

Jeff Powis¹, Allison McGeer, Carla Duncan, Ryan Goren, Joyce C S de Azavedo, Darrin J Bast, Sylvia Pong-Porter, Tony Mazzulli, Karen Green, Barbara Willey, Donald E Low

Affiliation

¹ Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario, Canada M5G 1X5.

Abstract

Fluoroquinolone susceptibility testing was performed on invasive group A streptococcus isolates from 1992-1993 and 2003 from Ontario, Canada. None were nonsusceptible to levofloxacin. Two of 153 (1.3%) from 1992-1993 and 7 of 160 (4.4%) from 2003 had a levofloxacin MIC of 2 mug/ml; all nine had parC mutations, and eight were serotype M6.

MeSH terms

Anti-Infective Agents / pharmacology*
DNA Topoisomerase IV / genetics
Drug Resistance, Bacterial
Fluoroquinolones / pharmacology*
Humans
Ontario / epidemiology
Population Surveillance
Streptococcal Infections / epidemiology*
Streptococcal Infections / microbiology*
Streptococcus pyogenes / drug effects*
Streptococcus pyogenes / genetics*

Substances

Anti-Infective Agents
Fluoroquinolones
DNA Topoisomerase IV