Abstract
TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+ immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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B-Lymphocytes / immunology
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Cell Cycle / genetics
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Core Binding Factor Alpha 2 Subunit
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Gene Rearrangement
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Hematopoietic Stem Cells / immunology
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Humans
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Immunoglobulins / analysis
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Immunoglobulins / genetics
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Immunophenotyping
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Neprilysin / biosynthesis
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Neprilysin / immunology
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Oncogene Proteins, Fusion / genetics*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Receptors, Antigen, T-Cell / analysis
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Receptors, Antigen, T-Cell / genetics
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Receptors, Immunologic / analysis
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Receptors, Immunologic / genetics*
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Recurrence
Substances
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Core Binding Factor Alpha 2 Subunit
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Immunoglobulins
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Oncogene Proteins, Fusion
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Receptors, Antigen, T-Cell
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Receptors, Immunologic
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TEL-AML1 fusion protein
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Neprilysin