Abstract
The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
MeSH terms
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Alzheimer Disease / drug therapy
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Amyloid Precursor Protein Secretases
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Aspartic Acid Endopeptidases / antagonists & inhibitors*
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Endopeptidases
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use
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Humans
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Models, Molecular
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Sulfones / chemistry
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Sulfones / pharmacology*
Substances
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Enzyme Inhibitors
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Sulfones
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Amyloid Precursor Protein Secretases
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Endopeptidases
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Aspartic Acid Endopeptidases
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BACE1 protein, human