Abstract
Background:
A regimen including interferon-alpha has become the standard of care in the treatment of chronic hepatitis C over the last decade. One rare adverse effect associated with the use of interferon-alpha is a granulomatous pulmonary reaction.
Case:
A unique case of uterine sarcoidosis associated with the use of interferon-alpha for chronic hepatitis C infection is presented.
Conclusion:
Gynecologists should be aware of a potential association between interferon-alpha therapy and granulomatous reactions occurring not only in the lung but also in the female genital tract.
MeSH terms
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Biopsy, Needle
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Follow-Up Studies
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Hepatitis C, Chronic / diagnosis
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Hepatitis C, Chronic / drug therapy*
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Humans
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Immunohistochemistry
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Interferon alpha-2
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Interferon-alpha / adverse effects*
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Interferon-alpha / therapeutic use
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Middle Aged
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Monitoring, Physiologic / methods
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Recombinant Proteins
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Risk Assessment
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Sarcoidosis / chemically induced*
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Sarcoidosis / pathology
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Severity of Illness Index
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Uterine Diseases / chemically induced*
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Uterine Diseases / pathology
Substances
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Interferon alpha-2
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Interferon-alpha
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Recombinant Proteins