E-cadherin-mediated adhesion is not the founding event of epithelial cell polarity in Drosophila

Trends Cell Biol. 2005 May;15(5):237-40. doi: 10.1016/j.tcb.2005.03.001.

Abstract

Formation of a polarized epithelial layer is a fundamental step during the development of multicellular animals. This process involves the coordinated action of adhesion molecules, actin remodeling and spatial organization of membrane traffic. A recent article describes a new hierarchy for the development of epithelial polarity in the early Drosophila embryo. Bazooka, a Par-3 homolog, is properly localized in the absence of adherens junctions, indicating that the formation of epithelial junctions is not the founding event of epithelial polarization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adherens Junctions / physiology
  • Animals
  • Cadherins / physiology*
  • Cell Adhesion / physiology
  • Cell Adhesion Molecules / physiology
  • Cell Polarity / physiology
  • Drosophila / cytology*
  • Drosophila / embryology
  • Drosophila / physiology
  • Epithelial Cells / physiology
  • Mammals
  • Models, Biological

Substances

  • Cadherins
  • Cell Adhesion Molecules