Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats

Hisahito Ishida; Yukihiko Shirayama; Masaaki Iwata; Ryuzou Kawahara

doi:10.1016/j.brainres.2005.04.007

Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats

Brain Res. 2005 Jun 7;1046(1-2):239-43. doi: 10.1016/j.brainres.2005.04.007.

Authors

Hisahito Ishida¹, Yukihiko Shirayama, Masaaki Iwata, Ryuzou Kawahara

Affiliation

¹ Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Japan.

PMID: 15869748
DOI: 10.1016/j.brainres.2005.04.007

Abstract

Learned helplessness, but not immobilization stress, decreased the numbers of neuropeptide Y (NPY)-positive cells (interneuron), but not calcitonin gene-related peptide (CGRP)-positive cells (mossy cell), in the hilus of the hippocampus. Subchronic treatment of learned helplessness rats, but not naive rats, with imipramine ameliorated the decrease in the number of NPY-positive cells. Therefore, NPY-positive cells in the hippocampus may contribute to depression.

Publication types

Comparative Study

MeSH terms

Animals
Antidepressive Agents, Tricyclic / administration & dosage*
Calcitonin Gene-Related Peptide / metabolism
Cell Count
Drug Administration Schedule
Helplessness, Learned*
Hippocampus / cytology
Hippocampus / drug effects
Hippocampus / metabolism*
Imipramine / administration & dosage*
Interneurons / drug effects
Interneurons / metabolism*
Male
Neuropeptide Y / metabolism*
Rats
Rats, Sprague-Dawley
Restraint, Physical / physiology

Substances

Antidepressive Agents, Tricyclic
Neuropeptide Y
Calcitonin Gene-Related Peptide
Imipramine