Current radiotherapic procedures and preservation of salivary function in patients with head and neck cancer

Acta Otorhinolaryngol Ital. 2004 Oct;24(5):275-8.

Abstract

Head and neck tumours have poor prognosis: with surgery and radiotherapy, local control is achieved but is associated with damage to speech and swallowing function. Conventional 2-D radiotherapy is based on one fraction of 1.8-2.0 Gy per day; increasing the number of fractions, a higher dose can be administered, with an increase in local control. Today, conventional treatment can be replaced by new techniques: with 3-D Conformal Radiotherapy, higher doses of radiation can be delivered to cancer cells while reducing the amount of radiation received by surrounding healthy tissues: Intensity Modulated Radiation Therapy permits an irregular dose distribution that conforms exactly to the volume of the target, increasing local tumour control and survival and decreasing radiation-induced side-effects.

MeSH terms

  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / radiotherapy*
  • Head and Neck Neoplasms / mortality
  • Head and Neck Neoplasms / radiotherapy*
  • Humans
  • Lymphatic Metastasis
  • Prognosis
  • Quality of Life
  • Radiotherapy / adverse effects*
  • Radiotherapy Dosage
  • Radiotherapy, Conformal*
  • Xerostomia / etiology*
  • Xerostomia / prevention & control