A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates

Joaquim Ruiz; Asunción Moreno; M Teresa Jimenez de Anta; Jordi Vila

doi:10.1016/j.ijantimicag.2004.10.016

A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates

Int J Antimicrob Agents. 2005 Jun;25(6):542-5. doi: 10.1016/j.ijantimicag.2004.10.016.

Authors

Joaquim Ruiz¹, Asunción Moreno, M Teresa Jimenez de Anta, Jordi Vila

Affiliation

¹ Centre de Salut Internacional, IDIBAPS, Hospital Clínic, Barcelona, Spain.

PMID: 15876526
DOI: 10.1016/j.ijantimicag.2004.10.016

Abstract

The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Substitution / genetics
Anti-Bacterial Agents / pharmacology*
Aza Compounds / pharmacology*
Campylobacter / drug effects*
Campylobacter / genetics
DNA Gyrase / drug effects
DNA Gyrase / genetics*
Drug Resistance, Bacterial / genetics*
Feces / microbiology
Fluoroquinolones
Humans
Microbial Sensitivity Tests
Moxifloxacin
Mutation*
Quinolines / pharmacology*

Substances

Anti-Bacterial Agents
Aza Compounds
Fluoroquinolones
Quinolines
DNA Gyrase
Moxifloxacin