Abstract
A series of appropriate aminoalkanolic derivatives 2- or 4-methylxanthone was synthesized and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scPtz) assays, and for neurotoxicity (TOX). The most interesting result was the anticonvulsant activity of (R,S)-2N-(6-chloro-2-xanthonemethyl-2N-methylamino-1-propanol hydrochloride (II, which displayed anti-MES and anti-scPtz activity. Some of the obtained compounds (I - IV and V - VII) were also tested for their effect on the circulatory system (the effect on normal electrocardiogram, protection against adrenaline-, barium-, calcium- and/or strophanthine-induced arrhythmias, the effect on the arterial blood pressure and respiratory movements) and acute toxicity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anticonvulsants / chemical synthesis
-
Anticonvulsants / pharmacology
-
Cardiovascular Agents / chemical synthesis*
-
Cardiovascular Agents / pharmacology*
-
Cardiovascular Agents / toxicity
-
Central Nervous System Agents / chemical synthesis*
-
Central Nervous System Agents / pharmacology*
-
Central Nervous System Agents / toxicity
-
Electrocardiography / drug effects
-
Guinea Pigs
-
Hemodynamics / drug effects
-
Lethal Dose 50
-
Magnetic Resonance Spectroscopy
-
Male
-
Mice
-
Rats
-
Rats, Wistar
-
Respiratory Mechanics / drug effects
-
Spectrophotometry, Infrared
-
Structure-Activity Relationship
-
Xanthones / chemical synthesis*
-
Xanthones / pharmacology*
-
Xanthones / toxicity
Substances
-
Anticonvulsants
-
Cardiovascular Agents
-
Central Nervous System Agents
-
Xanthones