Health research can play an important part in achieving the goals of improving health, economic development and reducing poverty, even though a review of the literature suggests that little attention is given to the subject. Mozambique as a developing country has scarce resources for health research and so its health research efforts need targeted at pressing concerns and be capable of influencing policy-making. A way forward is being developed so that position of policy-makers and researchers is clarified and co-ordination better organised. This will also involve a review of financing, formulation of agendas, the avoidance of wasted resources and improving management skills.