Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case-control study

C Lilla; T Koehler; S Kropp; S Wang-Gohrke; J Chang-Claude

doi:10.1038/sj.bjc.6602608

Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case-control study

Br J Cancer. 2005 Jun 6;92(11):2039-41. doi: 10.1038/sj.bjc.6602608.

Authors

C Lilla¹, T Koehler, S Kropp, S Wang-Gohrke, J Chang-Claude

Affiliation

¹ Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

Abstract

In a population-based study of 613 cases and 1082 controls, alcohol dehydrogenase 1B (ADH1B) genotype was not an independent risk factor for breast cancer, although the possibility was raised that it modifies risk associated with high levels of alcohol consumption (OR 1.1, 95% confidence interval (CI) 0.8-1.6 for ADH1B*1/*1 genotype vs 0.2, 95% CI 0.1-1.0 for ADH1B*2 carriers).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alcohol Dehydrogenase / genetics*
Alcohol Drinking / adverse effects*
Breast Neoplasms / epidemiology
Breast Neoplasms / etiology*
Breast Neoplasms / genetics*
Case-Control Studies
Central Nervous System Depressants / pharmacokinetics
Ethanol / pharmacokinetics
Female
Genotype
Germany / epidemiology
Humans
Middle Aged
Polymerase Chain Reaction

Substances

Central Nervous System Depressants
Ethanol
ADH1B protein, human
Alcohol Dehydrogenase