Abstract
A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Chalcone / chemical synthesis
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Chalcone / chemistry*
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Chalcone / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Neoplasms / drug therapy
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry*
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Pyrazoles / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Pyrazoles
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Chalcone