Abstract
A novel strategy of blocking the active site accessibility of MMP-9 by "multi-prong" surface binding groups is described.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Copper / chemistry*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Imino Acids / chemistry*
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Matrix Metalloproteinase 10
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Matrix Metalloproteinase 9 / chemistry
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Matrix Metalloproteinase Inhibitors*
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Metalloendopeptidases / antagonists & inhibitors
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Metalloendopeptidases / chemistry
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Structure-Activity Relationship
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Surface Properties
Substances
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Enzyme Inhibitors
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Imino Acids
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Matrix Metalloproteinase Inhibitors
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Organometallic Compounds
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Copper
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Metalloendopeptidases
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Matrix Metalloproteinase 10
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Matrix Metalloproteinase 9
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iminodiacetic acid