Abstract
Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Pairing
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Cytosine / analysis*
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Cytosine / chemistry
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DNA / chemistry*
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Guanine / analysis*
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Guanine / chemistry
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Hydrogen Bonding
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Nucleic Acid Conformation
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Nucleosides / chemical synthesis
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Nucleosides / chemistry*
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Oligonucleotides / chemistry
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Pyrimidinones / chemical synthesis
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Pyrimidinones / chemistry*
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Thymine / analysis
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Thymine / chemistry
Substances
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Nucleosides
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Oligonucleotides
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Pyrimidinones
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triplex DNA
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Guanine
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Cytosine
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DNA
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Thymine