Abstract
[structure: see text]. Lancifodilactone G (1), a novel, highly oxygenated nortriterpenoid featuring a partial enol structure and a spirocyclic moiety, was isolated from the medicinal plant Schisandra lancifolia. Its structure and stereochemistry were determined from extensive one- and two-dimensional NMR and mass spectral data, coupled with single-crystal X-ray analysis. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and showed anti-HIV activity with EC50 = 95.47 +/- 14.19 microg/mL and a selectivity index in the range of 1.82-2.46.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / chemistry
-
Anti-HIV Agents / isolation & purification*
-
Anti-HIV Agents / pharmacology
-
Crystallography, X-Ray
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Molecular Conformation
-
Molecular Structure
-
Plants, Medicinal / chemistry*
-
Schisandra / chemistry*
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification*
-
Triterpenes / pharmacology
Substances
-
Anti-HIV Agents
-
Drugs, Chinese Herbal
-
Triterpenes
-
lancifodilactone G