Abstract
The esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers have been prepared and their cytogenetic studies of structure-biological activity relationship were evaluated. The cytogenetic effects (sister chromatid exchanges (SCEs) induction and proliferation rate indices (PRIs) depression) by o-, m- and p-[N,N-bis(2-chloroethyl)amino] cinnamic acid were also investigated. Among the above compounds tested, those of the m-[N,N-bis(2-chloroethyl)amino] cinnamic acid and of the o-[N,N-bis(2-chloroethyl)amino] cinnamic acid ester of aza-homo-Hecogenin were more active in comparison to the others.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemical synthesis
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Antineoplastic Agents, Phytogenic / pharmacology
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Aza Compounds / chemical synthesis*
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Aza Compounds / pharmacology
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Cell Proliferation / drug effects
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Cinnamates / chemistry*
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Esterification
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Humans
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Isomerism
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Lymphocytes / drug effects
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Molecular Structure
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Mutagenicity Tests
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Nitrogen Mustard Compounds / chemical synthesis*
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Nitrogen Mustard Compounds / pharmacology
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Sapogenins / chemistry*
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Sapogenins / pharmacology
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Sister Chromatid Exchange / drug effects
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Sister Chromatid Exchange / genetics
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Aza Compounds
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Cinnamates
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Nitrogen Mustard Compounds
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Sapogenins
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cinnamic acid
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hecogenin