Abstract
Use of a third generation TSH assay enabled extremely low values of TSH to be detected through newborn screening. The use of a supplemental free thyroxine improved testing specificity. The hypothyroidism observed is believed to be secondary to suppression of the hypothalamic-pituitary-thyroid axis by placentally transferred maternal thyroxine.
MeSH terms
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Congenital Hypothyroidism
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Female
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Fetal Blood
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Hematologic Tests
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Humans
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Hypothyroidism / diagnosis*
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Hypothyroidism / etiology
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Infant, Newborn
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Infectious Disease Transmission, Vertical / prevention & control*
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Neonatal Screening / methods*
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Pregnancy
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Pregnancy Complications / blood
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Sensitivity and Specificity
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Thyrotoxicosis / blood
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Thyrotoxicosis / complications*
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Thyrotropin / blood*
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Thyroxine / administration & dosage