Abstract
The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthraquinones / chemistry*
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Bridged-Ring Compounds / chemistry*
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Bridged-Ring Compounds / isolation & purification
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Bridged-Ring Compounds / pharmacology
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Calcium / metabolism
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Cell Survival / drug effects
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Cells, Cultured
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Models, Molecular
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Molecular Structure
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Neurons / drug effects
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Neurons / metabolism
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Rats
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Streptomyces griseus / chemistry*
Substances
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Anthraquinones
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Bridged-Ring Compounds
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gephyromycin
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Calcium