Pre-transplant reduction of isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of pure red cell aplasia in major ABO-mismatched transplants

S Damodar; B George; J Mammen; V Mathews; A Srivastava; M Chandy

doi:10.1038/sj.bmt.1705031

Pre-transplant reduction of isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of pure red cell aplasia in major ABO-mismatched transplants

Bone Marrow Transplant. 2005 Aug;36(3):233-5. doi: 10.1038/sj.bmt.1705031.

Authors

S Damodar¹, B George, J Mammen, V Mathews, A Srivastava, M Chandy

Affiliation

¹ Department of Hematology, Christian Medical College, Vellore, India.

PMID: 15908965
DOI: 10.1038/sj.bmt.1705031

Abstract

Major ABO incompatibility in stem cell transplant recipients has been associated with pure red cell aplasia (PRCA). Reduction of incompatible isohaemagglutinin titres pre-transplant by various methods has been thought to reduce the incidence of PRCA. Our data suggest that pre-transplant reduction of incompatible isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of PRCA. We also failed to find any relationship between pre-transplant ABO isohaemagglutinin titre and the risk of developing PRCA.

MeSH terms

ABO Blood-Group System
Adolescent
Blood Group Incompatibility
Bone Marrow Transplantation / methods
Child
Child, Preschool
Erythrocytes, Abnormal / cytology*
Female
Hemagglutinins / analysis*
Hemagglutinins / chemistry
Hemagglutinins / metabolism
Hematopoietic Stem Cell Transplantation / methods
Histocompatibility Testing / methods*
Humans
Male
Red-Cell Aplasia, Pure / prevention & control*
Retrospective Studies
Stem Cells / cytology*
Time Factors
Transplantation Conditioning / methods

Substances

ABO Blood-Group System
Hemagglutinins