Abstract
Major ABO incompatibility in stem cell transplant recipients has been associated with pure red cell aplasia (PRCA). Reduction of incompatible isohaemagglutinin titres pre-transplant by various methods has been thought to reduce the incidence of PRCA. Our data suggest that pre-transplant reduction of incompatible isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of PRCA. We also failed to find any relationship between pre-transplant ABO isohaemagglutinin titre and the risk of developing PRCA.
MeSH terms
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ABO Blood-Group System
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Adolescent
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Blood Group Incompatibility
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Bone Marrow Transplantation / methods
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Child
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Child, Preschool
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Erythrocytes, Abnormal / cytology*
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Female
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Hemagglutinins / analysis*
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Hemagglutinins / chemistry
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Hemagglutinins / metabolism
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Hematopoietic Stem Cell Transplantation / methods
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Histocompatibility Testing / methods*
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Humans
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Male
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Red-Cell Aplasia, Pure / prevention & control*
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Retrospective Studies
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Stem Cells / cytology*
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Time Factors
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Transplantation Conditioning / methods
Substances
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ABO Blood-Group System
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Hemagglutinins