Abstract
New derivatives of 1,2,4-triazoline-5-thione system were obtained. The effects of both these compounds AP-I (3-phenoxymethyl-4-phenyl-D2-1,2,4-triazoline-5-thione) and AP-II (3-phenoxymethyl-4-ethyl-D2-1,2,4-triazoline-5-thione) on the central nervous system (CNS) of mice were studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Hydroxytryptophan / pharmacology
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Analgesics / chemical synthesis
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Analgesics / pharmacology
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Animals
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Anti-Anxiety Agents / chemical synthesis
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Anti-Anxiety Agents / pharmacology
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Anticonvulsants / chemical synthesis
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Anticonvulsants / pharmacology
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Body Temperature / drug effects
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Central Nervous System Agents / chemical synthesis*
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Central Nervous System Agents / pharmacology*
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Central Nervous System Agents / toxicity
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Indicators and Reagents
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Male
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Mice
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Pain Measurement
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Psychomotor Performance / drug effects
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Sleep / drug effects
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Thiones / chemical synthesis*
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Thiones / pharmacology*
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Triazoles / chemical synthesis*
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Triazoles / pharmacology*
Substances
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3-phenoxymethyl-4-R-D2-1,2,4-triazoline-5-thione
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Analgesics
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Anti-Anxiety Agents
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Anticonvulsants
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Central Nervous System Agents
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Indicators and Reagents
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Thiones
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Triazoles
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5-Hydroxytryptophan