Abstract
Sirolimus represents a major advancement in the field of solid organ transplantation and is being used as a rescue agent for acute and chronic rejection as well as for primary immunosuppression with good graft outcome. Although initial studies with sirolimus were in adults, now significant data have accumulated on the role of sirolimus in pediatric solid organ transplantation. This article reviews the current status of sirolimus in pediatric transplantation.
MeSH terms
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Child
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Graft Rejection / prevention & control
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Graft vs Host Disease / drug therapy
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Half-Life
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Humans
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / pharmacokinetics
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Immunosuppressive Agents / therapeutic use*
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Intestines / transplantation
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Kidney Transplantation / immunology
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Liver Transplantation / immunology
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Sirolimus / administration & dosage
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Sirolimus / adverse effects
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Sirolimus / pharmacokinetics
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Sirolimus / therapeutic use*
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Transplantation Immunology / drug effects
Substances
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Immunosuppressive Agents
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Sirolimus