Hardy-Weinberg testing of a single homozygous genotype

Genetics. 2005 Jul;170(3):1439-42. doi: 10.1534/genetics.105.043190. Epub 2005 May 23.

Abstract

No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Gene Frequency
  • Genetics, Population*
  • Genotype
  • Models, Genetic*
  • Statistics as Topic / methods*