Extending Xu's Bayesian model for estimating polygenic effects using markers of the entire genome

Genetics. 2005 Jul;170(3):1435-8. doi: 10.1534/genetics.105.040469. Epub 2005 May 23.

Abstract

In 2003, Xu obtained remarkably precise estimates of QTL positions despite the many markers simultaneously in his Bayesian model. We extend his model and Gibbs algorithm to ensure a valid posterior distribution and convergence to it, without changing the attractiveness of the method.

MeSH terms

  • Bayes Theorem
  • Chromosome Mapping / methods*
  • Models, Genetic*
  • Multifactorial Inheritance / genetics*
  • Quantitative Trait Loci*