Chromosome segregation: Aurora B gets Tousled

Curr Biol. 2005 May 24;15(10):R379-82. doi: 10.1016/j.cub.2005.05.009.

Abstract

Aurora B kinases play important roles during mitosis in eukaryotic cells; new work in Caenorhabditis elegans has identified the Tousled kinase TLK-1 as a substrate activator of the model nematode's Aurora B kinase AIR-2 which acts to ensure proper chromosome segregation during cell division.

Publication types

  • Review

MeSH terms

  • Animals
  • Aurora Kinase B
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / metabolism*
  • Chromosome Segregation / genetics*
  • Enzyme Activation / physiology
  • Histones / metabolism
  • Mitosis / physiology*
  • Phosphorylation
  • Protein Serine-Threonine Kinases / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • Histones
  • TLK-1 protein, C elegans
  • Aurora Kinase B
  • Protein Serine-Threonine Kinases
  • air-2 protein, C elegans