Cell cycle and cell-fate determination in Drosophila neural cell lineages

Trends Genet. 2005 Jul;21(7):413-20. doi: 10.1016/j.tig.2005.05.010.

Abstract

"Normal" development requires a finely tuned equilibrium between cell differentiation and cell proliferation. Important issues in development include whether the cell cycle controls the cell-fate determination and whether cell identity in turn regulates cell-cycle progression. Although, these issues are of general biological relevance, stereotyped Drosophila neural lineages are particularly suited to address these questions and have provided insights into the links between cell-cycle progression and cell-fate specification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Lineage
  • Cell Proliferation
  • Cytokinesis
  • Drosophila / physiology*
  • Gene Expression Regulation, Developmental*
  • Models, Biological
  • Nervous System / embryology*
  • Neurons / metabolism*
  • S Phase