Abstract
The coupling reaction of o-iodobenzoic acid with terminal alkynes by using a catalyst system of 10% Pd/C-Et3N-CuI-PPh3 has been studied in a variety of solvents. 3-Substituted isocoumarins were formed in good yields and with good regioselectivity when the reaction was performed in EtOH.
MeSH terms
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Alkynes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques*
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Coumarins / analysis
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Coumarins / chemical synthesis*
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Ethanol / chemistry
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Iodobenzoates / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Solvents
Substances
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Alkynes
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Coumarins
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Iodobenzoates
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Solvents
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Ethanol
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Palladium
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2-iodobenzoic acid