Abstract
Human gammadelta T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the Vgamma2Vdelta2+-T cell receptor (Vdelta2+ T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naïve alphabeta T cell proliferation and differentiation. We suggest that, upon microbial activation, Vdelta2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigen Presentation*
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Antigen-Presenting Cells / immunology*
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Bacterial Toxins / immunology
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / immunology
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Cell Differentiation
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Cell Polarity
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Dendritic Cells / immunology
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Enterotoxins / immunology
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HLA-DR Antigens / immunology
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HLA-DR Antigens / metabolism
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Histocompatibility Antigens Class II / immunology
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Histocompatibility Antigens Class II / metabolism
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Humans
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Immunity, Active
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Lymphocyte Activation
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Receptors, Antigen, T-Cell, gamma-delta / immunology*
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Superantigens / immunology
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocytes, Cytotoxic / cytology
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T-Lymphocytes, Cytotoxic / immunology
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Tetanus Toxoid / immunology
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Tuberculin / immunology
Substances
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Bacterial Toxins
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Enterotoxins
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HLA-DR Antigens
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Histocompatibility Antigens Class II
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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Superantigens
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Tetanus Toxoid
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Tuberculin
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enterotoxin F, Staphylococcal