p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

José Correa-Basurto; Iván Vázquez Alcántara; L Michel Espinoza-Fonseca; José G Trujillo-Ferrara

doi:10.1016/j.ejmech.2005.03.011

p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

Eur J Med Chem. 2005 Jul;40(7):732-5. doi: 10.1016/j.ejmech.2005.03.011. Epub 2005 Apr 25.

Authors

José Correa-Basurto¹, Iván Vázquez Alcántara, L Michel Espinoza-Fonseca, José G Trujillo-Ferrara

Affiliation

¹ Sección de Graduados y Departamento de Bioquímica, Escuela Superior de Medicina del Instituto Politécnico Nacional, Apartado Postal 42-161, C.P. 11340, Mexico City, Mexico.

PMID: 15935907
DOI: 10.1016/j.ejmech.2005.03.011

Abstract

Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

4-Aminobenzoic Acid / chemical synthesis*
4-Aminobenzoic Acid / pharmacology
Acetylcholinesterase / drug effects
Alzheimer Disease / drug therapy
Animals
Binding Sites
Cattle
Cholinesterase Inhibitors / chemical synthesis*
Cholinesterase Inhibitors / pharmacology
Models, Molecular

Substances

Cholinesterase Inhibitors
Acetylcholinesterase
4-Aminobenzoic Acid