A review of Streptococcus pneumoniae infection treatment failures associated with fluoroquinolone resistance

Jeffrey D Fuller; Donald E Low

doi:10.1086/430829

A review of Streptococcus pneumoniae infection treatment failures associated with fluoroquinolone resistance

Clin Infect Dis. 2005 Jul 1;41(1):118-21. doi: 10.1086/430829. Epub 2005 May 26.

Authors

Jeffrey D Fuller¹, Donald E Low

Affiliation

¹ Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, Ontario, Canada.

PMID: 15937772
DOI: 10.1086/430829

Abstract

We reviewed all of the published reports of cases of fluoroquinolone treatment failures for respiratory tract infection due to fluoroquinolone-resistant Streptococcus pneumoniae. There were 20 ciprofloxacin and levofloxacin treatment failures reported. Physicians should be aware, when treating pneumococcal respiratory tract infections in older patients with a fluoroquinolone, that clinical failures might occur, especially for patients with comorbid illnesses and a history of recent fluoroquinolone use.

Publication types

Case Reports
Review

MeSH terms

Aged
Aged, 80 and over
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Ciprofloxacin / pharmacology
Ciprofloxacin / therapeutic use
Drug Resistance, Bacterial*
Female
Fluoroquinolones / pharmacology*
Fluoroquinolones / therapeutic use
Humans
Levofloxacin
Male
Middle Aged
Ofloxacin / pharmacology
Ofloxacin / therapeutic use
Pneumococcal Infections / drug therapy*
Pneumococcal Infections / microbiology
Respiratory Tract Infections / drug therapy*
Respiratory Tract Infections / microbiology
Streptococcus pneumoniae / drug effects*
Treatment Failure

Substances

Anti-Bacterial Agents
Fluoroquinolones
Ciprofloxacin
Levofloxacin
Ofloxacin